Overmethylation: what is it and how does it work?

by | Jun 27, 2017 | Mental Health


Let’s avoid getting too technical: simply put, methylation makes things happen in your body.

Methylation adds a methyl group to our DNA, and in doing so is responsible for many biochemical activities in the body, which effect our energy levels, immune system, mood, the way we detoxify and many more. Having methylation work efficiently is important if you want to feel good.

Check out our post on undermethylation here, and lets talk about overmethylation now.


 So overmethylation is too much of a good thing! Effecting neurotransmitters, resulting in high serotonin levels, causing dopamine to hang out for longer: these chemicals, produced in our body, make us feel good and pleasure.

Sounds good right? However, this can cause emotional problems, confusion and poor motivation, to name a few. Overmethylators don’t always respond well to selective serotonin reuptake inhibitors (SSRI’s – commonly used antidepressants) or to the oral contraceptive pill (OCP) and they can develop drug psychosis.

Treatment options for Overmethylation

Overmethylators could have high copper levels, low zinc, high estrogen and high homocysteine levels. So may do well with folate, zinc, vitamin C and B vitamins.

If you suspect that you may be an overmethylator, it’s very important to consider your blood levels of the various nutrients and test within context of your situation.

I would recommend reading other related blog posts on pyroluria, MTHFR, homocysteine and undermethylation.

Contact us for testing and advice.



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