Leaky Gut Test
Think you might have a digestive tract that is “leaky”? Why not test then you know for sure and can target how to treat and give the appropriate time required for treatment work. Intestinal permeability can be measured using this lactulose/mannitol test.
Digestive Intestinal Permeability Testing (aka Leaky Gut)
Think you might have a digestive tract that is "leaky"? Why not test then you know for sure and can target how to treat and give the appropriate time required for treatment work. Intestinal permeability can be measured using this lactulose/mannitol test.
LEAKY GUT CAUSES DISEASE
Intestinal permeability is associated with many health conditions, including autism, autoimmune disorders, food sensitivities and inflammatory bowel diseases. 'Leaky gut’ causes disease because the perturbed intestinal barrier allows toxic molecules to enter the bloodstream.
The gastrointestinal tract has two main functions; a) to digest and absorb important nutrients for the body’s growth and function, and b) to act as a barrier to keep harmful solutes, luminal antigens and microorganisms from entering the blood. When the integrity of this complex system is disturbed and intestinal permeability exists, ill-health can develop.
DISEASES ASSOCIATED WITH INCREASES PERMEABILITY
Symptoms and Conditions Associated with Intestinal Permeability include; Abdominal recurrent pain, Food allergy & sensitivity, Acute pancreatitis Inflammatory bowel disease, Aging, Inflammatory joint disease, Irritable bowel syndrome, Ankylosing spondylitis, Malabsorption, Atopic dermatitis, Autism, Rheumatoid arthritis, Schizophrenia, Coeliac disease, Type I diabetes and allergy.
In addition to assessing leaky gut, this test can also help diagnose malabsorption. If a low level of mannitol which normally penetrates the intestinal epithelium is observed, it may indicate malabsorption of small molecules and possible atrophy of the intestinal villi. It is also useful in monitoring the effectiveness of treatment therapies.
UNDERSTANDING THE TEST
This test which assesses lactulose and mannitol recovery has been used to study numerous disorders which are associated with increased intestinal permeability. The lactulose/mannitol test can also be used to monitor improvements or deterioration in intestinal permeability as a result of therapy, disease or drug use. This has been performed in the case of assessing the effect of IGF1 supplementation on premature neonates, rhubarb on septic patients, bifidobacter on preterm infants, and chemotherapy on ovarian and breast cancer patients. Furthermore, the intestinal permeability test has been used to monitor the compliance and effectiveness of a gluten-free diet in patients with Coeliac disease. After one year of following the dietary plan, patients that were negative for the antigliadin antibody test (which shows dietary compliance), had lowered intestinal permeability.
HOW THE TEST WORKS
The test works on the principle that small molecules (i.e. mannitol) are readily absorbed by the intestinal villi, whilst larger molecules such as disaccharides (i.e. Lactulose) are not. These water soluble non-metabolised sugar molecules after penetrating the intestinal tract are excreted into the urine. Under normal circumstances the ratio of lactulose to mannitol in urine is low (i.e lactulose is not absorbed), mannitol is absorbed. When the structure of the intestinal epithelium is jeopardized (‘leaky gut’ is present), the large sugar molecule can permeate the mucosa and is recovered in the urine. In this situation the level of lactulose is increased in the urine and therefore the ratio of lactulose to mannitol is high. A 6 hour urine specimen is collected after mannitol and lactulose are ingested. Result Turnaround Time: Two weeks after receipt of sample
Want to know more about leaky gut - https://naturalhealthmedicine.com.au/leaky-gut-syndrome/