Hypothyroidism has to be one of the most diagnosed conditions these days! Hypothyroidism is basically an under active thyroid, the thyroid hormones regulate our metabolism and a common symptom when this is not happening is fatigue!
All The Signs & Symptoms
Depression, fatigue, lethargy, forgetfulness, decreased concentration, memory deficit, slow thinking, cold intolerance, decreases sweating, headaches, weakness, cramps, myalgia, arthralgia, hypercholesterolaemia, diastolic hypertension, cold extremities, iron deficiency, shortness of breath, constipation, flactulence, bloating, puffy eyes, goitre, dysphagia, sore throat, lowered immune response, recurrent infections, impaired kidney function, low libido, infertility, menstrual irregularities, fibrocystic breast disease, menorrhagia, hyperprolactinaemia, impotence, dry skin, coarse skin, brittle and coarse hair and nails, hair loss, weight gain, difficulty losing weight, oedema.
TSH – What is it and where should it be?
TSH is the hormone released in the brain in response to low levels of thyroid hormones T3 & T4: its job is to stimulate the thyroid to release more thyroid hormones, so TSH levels elevate when thyroid hormones are low and decrease as thyroid hormones rise. Unfortunately, the upper level for most labs is too high (usually 4.12mIU/L). Even though the National Academy of Clinical Biochemistry in 2005 recommended the upper limit of TSH to be lowered to 2.5mIU/L, this news hasn’t it made it into orthodox medical practice, resulting in many people being told that their thyroid looks fine. This in turn creates a situation where further investigations are made later rather than sooner.
THYROID CHECK LIST
Lets take a quick look at the ideal, check list of the thyroid:
Thyroid stimulating hormone is released by the pituitary gland in the brain and stimulates the thyroid gland to release thyroid hormones, primarily T4 and T3. It makes sense to check that the thyroid is being sent its message to produce hormones.
Thyroxine (T4) is the main thyroid hormone released and converts to the active form triiodothyronine (T3). Inadequate amounts of T4 are suggestive of iodine deficiency. The ratio between T4 and T3 partly reveals what the thyroid is doing.
Thyroperoxidase antibodies (TPOAb), thyroglobulin antibodies (TGAb), thyroid stimulating thyroid receptor antibodies (TRAb) are antibodies that when elevated suggest thyroid autoimmunity (the immune system attacking the thyroid), indicating possible inflammation of the thyroid. Levels are normally elevated in diseases of the thyroid such as Hashimoto’s thyroiditis, thyroid carcinoma and Grave’s disease. TSH receptor auto-antibodies generally stimulate the TSH receptor causing Grave’s disease.
Reverse T3 (rT3)
Is an inactive form of T3 that is produced in the body particularly during periods of stress, this protects metabolism becoming too unstable during times of stress. When elevated can suggest that stress (physical or emotional by the way) is effecting the thyroid.
Cortisol is our stress hormone and effects thyroid function and therefore can be useful in assessing if the cause is coming from the adrenal glands (which release cortisol).
Iodine makes up the structure of the thyroid hormones correctly assessing iodine status is important there are urinary spot and urinary loading tests, the loading test may be more accurate but may not be advisable in certain situations (those taking pharmaceutical thyroid drugs such as thyroxine cannot do the loading test) and therefore a spot test can be used but must always be completed with a urinary creatinine test to ensure accurate interpretation. Selenium is responsible for converting T4 to T3, making it supper important if we want enough T3 available to our cells. Zinc effects both TSH and thyroid hormone levels. Iron deficiency effects thyroid hormones from being made.
*Note the hair loss attributed to hypothyroidism may not improve without zinc supplementation, even if thyroxine – the pharmaceutical drug prescribed for hypothyroidism, is given.
IODINE DEFICIENCY IS RE-EMERGING IN AUSTRALIA
We need to pay close attention to this, as iodine is critical to humans and especially growing children. But before you just go off and start supplementing with large doses of iodine, my recommendation would be that you ensure you know exactly what is happening with all of the above levels (please note we are suggesting caution with HIGH doses). Starting with low doses and building up is a sensible approach, the thyroid hates being shocked!
*kelp granules are a great source of iodine and can be sprinkled into food like you would salt and pepper – this will not be an adequate dose for those with severe deficiencies, but great for those who want to include iodine in their diet.
Gardner, DG, 2011. Greenspan’s Basic & Clinical Endocrinology. 1st ed. China: The McGraw-Hill Companies.